A case of familial cold urticaria is reported in a 29-year-old male who showed generalized erythematous macules and papules, finally an urticarial eruption shortly after cold exposure, particularly in cold windy weather with damp. Coincidentally,
systemic symptoms such as headache. Fever and chills, arthralgia, and conjunctival injection were acompanied. Autosomal dominant inheritance was found on examination of his pedigree inwhich 11 of 18 members showed similar clinical manifestations.
Routine laboratory findings were within normal limits except mild leukocytosis and elevated erythrocyte sedimentation rate.
Biopsy specimen from a cold-evoked lesion revealed mild edema and mild perivascular infiltrations composed ofneutrophils, eosinophils and lymphocytes in the dermis. Treatments included several widely-used antihistaminics, but turned out to be
unsatisfactory.
(Kor J Dermatol 1993 : 31 (1) : 87-91)
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